Two Cases of Adenosquamous Cell Carcnoma of the Intrahepatic Bile Duct

Kazuo Suga, Masato Furukawa, Toshnori Nakata, Toshiomi Kusano, Yiqin Lin, Kazunori Tashiro, Kazuyuki Tachibana, Kunihisa Miyazaki

Department of Surgery, Nagasaki Chuou National Hospital

Adenosquamous cell carcinoma comprises both adenocarcinoma and squamous cell carcinoma coexisting in the same cancer nest. Such carcinoma originating in the intrahepatic bile duct has seldom, if ever been reported-We found, only 15 cases in the literature. We have recently experienced 2 such cases (a 72-year-old man and a 69-year-old man). Examination of the 17 cases including our 2 revealed a sex ratio of l0:7 without a great sex difference, right lobe and left lobe as the site of occurrence in 8 and 9 cases, respectively, and hepatic symptoms in particular as chief complain, folowed by icterus, etc. The treatment is, in principlex, extirpation of the tumor by hepatectomy, but with poor operative result and very unfavorable prognosis (15 of the patients died, the exception were our 2). The pathogenesis of the present disease may partially involve some chronic stimuli such as biliary retention and bile stones to the bile duct. It is suggested that cases with stenosis of the hepatic hilm and intrahepatic stones should be coped with, taking the possible complication of adenosquamous cell carcinoma into consideration.

Key words
cholangioma, adenosquamous cell carcinoma

Reprint requests
Kazuo Suga Ikitsuki Hospital 2965 Yamadamen, Ikitsuki-chou Kitamatsuura-gun, Nagasak, 857-44 JAPAN

Accepted
December 13, 1989

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