Effect of Single and Combined Administration of Caerulein, Hydrocortisone and FOY-3OS on Regeneration of the Pancreas after 9O% Pancreatectomy in Rats

Ikuo Oikawa, Koichi Hirata, Hiroshi Hayasaka

Department of Surgery (Section 1), Sapporo Medical College

We studied the effect of single and combined administration of caerulein, hydrocortisone and FOY-305 on the regeneration of the remnant pancreas after 90% pancreatectomy in rats. After a sham operation or a 90% pancreatectomy, rats were given with the three agents either singly or in combination. After the rats were killed, the pancreas was weighed and examined for tissue amylase activity, tissue protein content and total DNA content. The results were as follows: 1) In the sham operation group, caerulein produced a significant trophic effect and the trophic effect in the combined administration group was greater than that in the single administration group. 2) In the 90% pancreatectomized group, hydrocortisone produced significant trophic effect and the trophic effect in the combined administration group was greater than that in the single administration group. These data show that the effect of the combined administration of caerulein, hydrocortisone and FOY-305 on the growth of the pancreas was greater than that of the drugs given singly.

Key words
pancreas regeneration, caerulein, hydrocortisone, trypsin inhibitor

Reprint requests
Ikuo Oikawa First Department of Surgery, Sapporo Meidical College
West-16, Sough-1, Chuo-ku, Sapporo, 060 JAPAN

Accepted
December 13, 1989

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