A Clinicopathological Features of Liver Metastasis in Colorectal Cancer

Naoki Oda, Hiromi Sarashina, Norio Saitoh, Masao Nunomura, Masayuki Yokoyama, Masato Ihara, Hajime Nakayama, Yoshinori Shirai, Toshio Ohmori, Nobuhiro Takiguchi, Masaru Miyazaki, Katsuji Okui

First Department of Surgery, Chiba University School of Medicine

A retrospective review of 78 colorectal cancers with liver metastasis (synchronous, 51; metachronous, 27) out of 407 colorectal cancers resected in our institute was undertaken to detect the risk factors of liver metastasis. The average size of primary tumors with synchronous metastasis to the liver was significantly larger than that of tumors with no metastasis. Furthermore, the invasive type of tumor with a crater showed a higher incidence of liver metastasis than the limited type of tumor with a crater, although the site of the primary tumor had no relation to the incidence of metastasis. From the pathological point of view, the following findings were considered to be important risk factors of liver metastasis: 1) moderately differentiated type, 2) invasion into the perirectal adiose tissue in the rectum or to the serosal surface in the colon, 3) severe involvement of lymph nodes (n2), 4) marked lymphatic and hematogenous permeation (1y3, v2). It was concluded that total judgment based on many factors including the above pathological findings was important for the precise prediction of liver metastasis in colorectal cancer.

Key words
colorectal cancer, risk factor of liver metastasis, venous invasion of colorectal cancer

Reprint requests
Naoki Oda First Department of Surgery, Chiba University School of Medicine
1-8-1 Inohana, Chiba, 280 JAPAN

Accepted
May 9, 1990

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