Therapeutic Effects for Recurrence After Resection of Hepatocellular Carcinoma

Hiroshi Kohnosu, Takeshi Hironaka¹⁾, Kenji Tsukamoto²⁾, Atsushi Horii, Keitaroh Kan, Yoshikazu Shimode, Hayazoh Kubo, Kohji Omori, Hiroyuki Makino, Kenichiroh Hamagashira, Hirosumi Itoi, Teruhisa Sonoyama, Kazuyo Naitoh, Hisakazu Yamagishi, Takahiro Oka

The Second Department of Surgery, Kyoto Prefectural University of Medicine
1) Kohoku General Hospital
2) Department of Surgery, Akashi Municipal Hospital

Fifty-five patients with recurrence of surgically resected hepatocellular carcinoma were assesed for clinical outcome in reference to type of recurrence, time of recurrence and therapy. Patients with a single intrahepatic recurrence had a better survival rate two years after recurrence than those with multiple intrahepatic or extrahepatic recurrence; 87.5% with single (n=11), 40.1% with multiple (n=30) and 13.4% with extrahepatic (n=14) metastatic lesions. In 30 cases of multiple intrahepatic recurrence, death within a year after recurrence occurred in 8 of 15 patients (53.3%) with recurrence within a year after hepatectomy, wereas it occurred in only one of 15 patients (6.7%) with recurrence more than one year after hepatectomy. In regard to treatment for recurrence, survival rate two years after recurrence was 34.3% of 10 patients treated by reoperation [OP group], 64.9% of 27 patients treated by transcatheter arterial embolizatin [TAE (+) group], and 6.9% of 18 patients treated by chemotherapy alone [TAE (-) group]. The outcome in the TAE (-) group was poorer, but no significant difference was observed between the OP group and the TAE (+) group.

Key words
prognosis of recurrent hepatocellular carcinoma, reoperation for recurrent hepatocellular carinoma, transcatheter arterial embolization for recurrent hepatocellular carcinoma

Reprint requests
Hiroshi Kohnosu The Second Department of Surgery, Kyoto Prefectural University of Medicine
Kawaramachi-hirokoji, Kamigyoku, Kyoto, 602 JAPAN

Accepted
June 13, 1990

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