A Case Report of pm Gastric Cancer Producing Alpha-Fetoprotein

Shiro Nakae, Yoko Maekawa, Norio Kohno, Seishi Nakaya, Shigeo Kaneko, Jun Fujiwara, Yoichi Saitoh*

Department of Surgery, Center for Adult Disease, Hyogo
*First Department of Surgery, Kobe University School of Medicine

A case of alpha-fetoprotein (AFP) producing pm gastric cancer without liver and lymph node metastasis is reported. The paient was a 69-year-old male whose serum AFP level was abnormally high, 1086 ng/ml. X-ray and endoscopic examination revealed a tumor (Borrmann type 2) at the body of the stomach. It was confirmed as Group V by biopsy and the pyloric side of the stomach was resected and R₂ curettage was performd. Histopathological examination disclosed poorly differentiated adenocarcinoma admixed with relatively differentiated areas, limited to the tunica muscularis propria without lymph node metastasis. Immunohistochemically, the less differentiated and medullary areas were strongly positive and the relatively differentiated areas were weakly positive for AFP. The serum AFP level became normal after the operation and no recurrence was observed 1 year and 5 months later.

Key words
alpha-fetoprotein producing gastric cancer, immunohistochemical stain

Reprint requests
Shiro Nakae Department of Surgery, Center for Adult Disease, Hyogo
13-70 Kitaouji, Akashi, 673 JAPAN

Accepted
May 9, 1990

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