Significance of Clinicopathologic Details and Prognoses in Colorectal Cancers Limited to the Proper Muscle Layer -Comparison with Cancers Extend Beyond the Proper Muscle Layer-

Yoichi Sakurai, Akahito Aoki, Shigeo Okazeri, Toshio Kanai, Hideo Shimada, Takako Sunaga, Yoshiro Saikawa, Ryuichi Nakayama

Department of Surgery, Hiratsuka City Hospital

Among 327 patients undergoing surgery for colorectal cancer in Hiratsuka City Hospital from 1970 through 1989, 53 patients whose cancer invasion was limited within the mucosa, submucosa and proper muscle (the pm group, which was defined by general rules for clinical and pathological studies on cancer of colon, rectum and anus) were selected and were compared with 212 patients whose cancer extended from the mucosa beyond the proper muscle and did not definitely infiltrate into other organs (the ss, s group, which was also defined by the rules described above) in respect to the clinicopathologic details and prognosis. The mean age in the pm group was 64.1 years, which is older than that in the ss, s group, but the difference was not significant. The frequency of rectal tumors in the pm group was 58.5% which was significantly higher than that in the ss, s group (p<0.01). The mean tumor size in the pm group was 4.2 cm, whereas that in the ss, s group was 5.5 cm and was significantly smaller than that in the ss, s group. There were no patients who showed distant metastasis in the pm group. The rate of regional lymph node metastasis in the pm group was 24.5%, whereas that in ss, s group was 47.6%. There was a significantly lower frequency of regional lymph node metastasis in the pm group (p<0.01). The cumulative five- and ten-years-survival rates for patients in the pm group were 83.9 and 74.0%, respectively which were significantly better than those for patients in the ss, s group. The cumulative five- and ten-years-survival rates for the ss, s group were 50.7 and 42.7%, resectively.

Key words
colorectal cancers, clinicopathologic details of colorectal cancers limited to the proper muscle layer, prognoses of colorectal cancers limited to the proper muscle layer

Reprint requests
Yoichi Sakurai Department of Surgery, Hiratsuka City Hospital
1-19-l Hiratsuka-city, 254 JAPAN

Accepted
July 10, 1990

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