Study of Serial Changes in Prostaglandin I₂ and Thromboxane A₂ (TXA₂) Levels after Canine Liver Resection under Hepatic Inflow Clamp and Effect of TXA₂ Synthetase Inhibitor

Kazuhisa Yabushita

Department of Surgery II, Kanazawa University School of Medicine

As a possible means of preventing ischemic liver injury, serum thromboxane A₂ (TXA₂) and prostaglandin I₂ (PGI₂) levels were investigated regarding tissue injury after liver resection under hepatic inflow clamp. Mongrel dogs were divided into three groups. The control group recieved 25% liver resection. The clamp group recieved 25% liver resection after hepatic inflow clamp for 60 minutes. The OKY group was given OKY-046 and then treated in the same way as the clamp group. Blood sumples were collected for 1 week after the operation. During the postoperative days, TXB₂ levels in the clamp group increased more gradually than those in the control and OKY groups. In contrast, 6-keto-PGF_1α, levels showed no significant differences among the three groups. Also in liver functions and blood coagulating functions, the clamp group had significantly abnormal levels compared with the control and OKY groups. In pathological findings of liver tissues 7 days after the operation, centrolobular coagulative necrosis was observed in the clamp group, but no abnormal findings were observed in the control and OKY groups. These findings suggest that TXA₂ is important for progression of tissue injury after liver ischemia and that TXA₂ synthetase inhibitor is effective for prevention of ischemic liver injury.

Key words
The pringle manoeuvre, liver ischemic injury damage, thromboxane A₂, prostaglandin I₂, OKY-046

Reprint requests
Kazuhisa Yabushita Department of Surgery II, School of Medicine, Kanazawa University
13-1 Takara-machi, Kanazawa, 920 JAPAN

Accepted
September 12, 1990

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