Effect of the Duration of Obstructive Jaundice on Acute Gastric Ulceration and on the Prevention of Acute Gastric Ulcers by Biliary Drainage in Rats with Obstructive Jaundice

Yasuhiko Kamiyama, Iwao Sasaki, Tetsuya Matsuo, Yoshio Matsuda*, Hiroo Naito, Seiki Matsuno

First Department of Surgery, Tohoku University, School of Medicine
*Department of Surgery, Saka Sogo Hospital

To determine the effect of the duration of obstructive jaundice on acute gastric ulceration and on the prevention by biliary drainage of acute gastric ulcers in rats with obstructive jaundice, ulcer indices (UI), gastric mucosal potential difference (GMPD) and intragastric pH (IGpH) were measured in rats jaundiced for 2 and 4 wk with or without biliary drainage and subjected to restraint and water immersion stress. UI were also measured in rats jaundiced for 6 wk. The UI values in the rats jaundiced for 4 wk were higher than in the rats jaundiced for 2 wk. The UI values were highest in the rats jaundiced for 6 wk. The biliary drainage was effective in the rats jaundiced for 2 wk, but not in those jaundiced for 4 wk in the prevention of acute gastric ulcers. Acute gastric ulcers were induced only by biliary drainage in the rats jaundiced for 4 wk. The decreases in GMPD were prevented by biliary drainage in both the rats jaundiced for 2 wk and those jaundiced for 4 wk, but its effect was more evident in the 2-wk jaundiced rats than in those jaundiced for 4 wk. The IGpH in each group of rats was not influenced by the duration of obstructive jaundice or the biliary drainage. These results suggest that 1) long duration of obstructive jaundice aggravates acute gastric ulcers and damages the gastric mucosal deffense mechanism; 2) long duration of jaundice reduces the preventive effect of biliary drainage on gastric ulcerations and acute gastric ulcers are induced by biliary drainage when jaundice is very prolonged.

Key words
acute gastric ulcers in obstructive jaunduce, duration of jaundice, effect of biliary drainage, ulcer index, gastric mucosal potential difference

Reprint requests
Yasuhiko Kamiyama First Department of Surgery, Tohoku University, School of Medicine
1-1 Seiryocho, Aobaku, Sendai, 980 JAPAN

Accepted
February 13, 1991

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