Clinical Evaluation of Ciclosporin and the Immunosuppressant FK506 on Pancreaticoduodenal Allotransplantation in Dogs

Koshi Sato, Kiyoshi Imai, Ken Matsui, Michio Sugino, Yoshisuke Nakayama, Tsunemasa Takishima, Muneki Yoshida, Tsuneo Osakabe, Hiroyoshi Mieno, Harumi Omiya, Yoshiki Hiki, Akira Kakita

Department of Surgery, School of Medicine, Kitasato University

Pancreaticoduodenal allotransplantation was performed to evaluate ciclosporin (CSA) and FK506 in dogs. Forty-two mongrel dogs were used for these experiments. There were three experimental groups, group 1 (n=5), controls, no immunosuppression was given. In group 2 (n=10), intramuscular injections of CSA 20 mg/kg/day were given initially, this was reduced to 10 mg/kg/day 3 weeks later. In group 3 (n=6), 0.1∼0.3 mg/kg/day of FK506 was given intramuscularly. The conclusions of these experiments were following. 1) Significant prolongation of pancreaticoduodenal allograft survival was obtained with CSA and FK506 compared with control animals without immunosuppression. 2) Toxicity of FK506 was loss of appetite and weight loss. 3) In group 1 without immunosuppression, all dogs died of acute rejection. In group 2 with CSA, two dogs died of acute rejection, eight dogs died of chronic rejection. In group 3 with FK506, two dogs died of acute rejection, four dogs died of chronic rejection.

Key words
pancreaticoduodenal allotransplantation, ciclosporin, FK506, immunosuppression

Reprint requests
Koshi Sato Department of Surgery, School of Medicine, Kitasato University
1-15-1 Kitasato, Sagamihara, 228 JAPAN

Accepted
June 5, 1991

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