Taurocholate-induced Gastric Damage in Rats with Obstructive Jaundice and Biliary Drained Rats

Tetsuya Matsuo, Iwao Sasaki, Yasuhiko Kamiyama, Hiroo Natioh, Yuji Funayama, Seiki Matsuno

The First Department of Surgery, Tohoku University School of Medicine

To investigate the effects of obstructive jaundice and biliary drainage on taurocholate (TCA)-induced gastric lesions, male Sprague Dawley rats weighting about 200 g were divided into three groups as follows; control group, obstructive jaundice group and biliary drained group. In obstructive jaundiced rats the ulcer index (UI) after administration of 100 mg of TCA was higher than in control rats. Biliary drainage reduced the UI. In both obstructive jaundiced rats and biliary drainage reduced the UI. In both obstructive jaundiced rats and biliary drained rats the hexosamine contents of the mucosa was lower than that of the control rats. The gastric mucosal potential difference (PD) was more markedly decreased after administration of TCA and didn't recover as well in obstructive jaundiced rats as in the control rats. In biliary drained rats the PD was improved. Intragastric pH was not changed immediately after TCA administration in any of the groups but 3 hours later it was higher in obstructive jaundiced rats. These results suggested that TCA causes a more severe gastric lesion in obstructive jaundiced rats, and that biliary drainage reduces ulcer formation by improving the defense mechanism.

Key words
cytoprotection, taurocholate, hexosamine, gastric mucosal potential difference, intragastric pH

Reprint requests
Tetsuya Matsuo The First Department of Surgery, Tohoku University School of Medicine
1-1 Seiryoumachi Aoba-ku, Sendai, 980 JAPAN

Accepted
April 1, 1992

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