Effect of H₂-receptor Antagonist and Teprenone on Experimental Acute Gastric Mucosal Lesion

Chikara Kunisaki, Mitsugi Sugiyama*, Toshiro Yamamoto, Hiroshi Katamura

Second Department of Surgery, Critical Care and Emergency Medicine*, Yokohama City University School of Medicine

This investigation was performed to study the prophylactic and therapeutic effects of drugs for acute gastric mucosal lesions (AGML) in a pathophysiological model. Male Wistar rats (250-300 g) with obstructive jaundice were exposed to cold water immersion stress and divided into three groups: controls, a cimetidine (50-100 mg/kg i.p.) group and a teprenone (200 mg/kg/day p.o.) group. Various defensive factors and aggressive factors were evaluated biochemically and histologically at intervals. When gastric mucosal blood flow was estimated as 1.0 at the preexposure, Cimetidine maintained it in a dose-dependent manner in addition to suppressing gastric acid secretion even 6 hours after stress exposure at a degree of 0.278±0.07 as compared to 0.154 ± 0.007 in non-treated group. Teprenone maintained some defensive factors such as gastric mucosal blood flow, transmucosal potential difference and gastric mucosal hexosamine content, and suppressed aggressive factors such as gastric mucosal glycosidase and gastric mucosal thiobarbituric acid reactants without inhibition of gastric acid secretion after stress. The decrease in gastric mucosal blood flow was suppressed to a degree of 0.303±0.081 and 0.225±0.038 at 3 hours and 6 hours, respectively. From the results, it was concluded that H₂-receptor antagonists and agents such as teprenone which increase defensive factors are useful as prophylaxis and therapy for AGML.

Key words
acute gastric mucosal lesion, defensive factors, aggressive factors

Reprint requests
Chikara Kunisaki Department of Surgery, Fujisawa City Hospital
2-6-1 Fijisawa, Fujisawa City, 25l JAPAN

Accepted
July 6, 1992

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