A Case of Complete Remission of Multiple Liver Metastases from Gastric Cancer by the Treatment of Intrahepatic Infusion of Interleukin-2 (IL-2) with Mitomycin C (MMC) and 5-Fluorouracil (5-FU) Through a Subcutaneous Port

Kiyotaka Okuno, Akira Tanaka, Ichizo Nakajima, Noriaki Tochihara, Toshihiro Yoshida, Hiroaki Ohnishi, Masayuki Yasutomi

The First Department of Surgery, Kinki University School of Medicine

The authors present a case of complete remission of multiple liver metastases from gastric cancer as a result of treatment by hepatic artery infusions of interleukin-2 (IL-2) with mitomycin C (MMC) and 5-fluorouracil (5-FU). A 54-year-old man, diagnosed as having extensive gastric cancer that had invaded to the lower esophagus with a solitary liver metastasis, underwent total gastrectomy, splenectomy with partial esophagectomy with regional lymph node dissection, and wedge resection of the liver. Six months after the operation, multiple liver metastases were detected by CT scanning and ultrasonography of the liver. He was readmitted and a port for hepatic arterial infusion was implanted. IL-2 combined with MMC and 5-FU was given via the hepatic artery once or twice weekly for 6 months. Judging from the CT scan and angiography taken after one month, the multiple metastatic foci noted before therapy had clearly disappeared. At the time of his last physical examination in May 1992, a liver CT scan showed no tumor recurrence.

Key words
hepatic artery infusion, interleukin-2, liver metastases

Reprint requests
Kiyotaka Okuno The First Department of Surgery, Kinki University School of Medicine
377-2 Ohno-higashi, Osaka-sayama, Osaka, 589 JAPAN

Accepted
July 6, 1992

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