Evaluation of Nodal Involvement and Expression of Oncoprotein as Prognostic Factors in Gastric, Bile duct, and Pancreatic carcinomas

Koichi Motojima, Takashi Kanematsu

Second Department of Surgery, Nagasaki University School of Medicine

Recentstudies have shown that oncoprotein expression is correlated with poor prognosis of cancer patient. To evaluate the importance of nodal involvement and oncoprotein expressions as prognostic factors, we analyzed 80 patients with advanced gastric, 60 patients with pancreatic carcinomas by immunohistologic assay. Nodal involvement was the most important prognostic indicator in gastric cancer. High incidences of EGFR expression were shown in bile duct and pancreatic carcinoma. Survival of patients with EGFR-positive cancer was shorter than those with EGFR-negative cancer. These results suggested that EGFR expression is of prognostic value in the recurrence of bile duct and pancreatic carcinomas.

Key words
prognostic factor, nodal involvement, oncoprotein expression

Reprint requests
Koichi Motojima Second Department of Surgery, Nagasaki University School of Medicine
1-7-1 Sakamoto, Nagasaki, 852 JAPAN

Accepted
June 14, 1993

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