Prognostic Factor of Gastric Carcinoma-Usefulness for Prognostic Factor and Improvement of Prognosis in Patients with Gastric Cancer

Osamu Kojima, Yuuji Yoshioka, Hiroshi Minato, Ryouji Iiduka, Eigo Otsuji, Masataka Shimotsuma, Hiroki Taniguchi, Akeo Hagiwara, Tetsurou Yamane, Toshiharu Yamaguchi, Seiji Sawai, Toshio Takahashi

First Department of Surgery, Kyoto Prefectural University of Medicine

In this study, we examined the association of estrogen receptors (ER) and progesterone receptors (PgR) with the prognosis of 90 advanced gastric cancer patients and clinicopathological variables. Furthermore, we investigated whether endocrine therapy was effective for gastric cancer. ER and PgR were immunohistologically investigated in 90 advanced gastric cancer patients who underwent curative resection. The cumulative 8-year survival rate was 62.7% in the ER-negative patients and 15.7% in the ER-positive patients, the difference being significant. A significant difference between the PgR status and 8-year survival rate was also observed. The ER-positive cancers showed a higher rate of proliferating cell nuclear antigen-positive cells than those of ER-negative cancers. In the scirrhous type of gastric cancer, patients with administration of tamoxifen had a better prognosis than those without tamoxifen. In conclusion, the present data suggest that ER and PgR in gastric cancer tissues are useful prognostic parameters for gastric cancer, and endocrine therapy might be an effective treatment for ER-positive cancer.

Key words
prognostic factor of gastric cancer, estrogen receptor, progesteron receptor

Reprint requests
Osamu Kojima First Department of Surgery, Kyoto Prefectural University of Medicine
465 Kajiicho, Kawaramachi, Kamigyo-ku, Kyoto, 602 JAPAN

Accepted
June 14, 1993

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