A Study on c-Ki-ras Oncogene Point Mutation in Synchronous Multiple Gastric Carcinoma

Kazuaki Kido, Ryunosuke Kumashiro, Chiaki Sano, Shigemichi Yamasaki, Kouichi Tanaka, Sadamitsu Inutsuka

Second Department of Surgery, School of Medicine, Fukuoka University

In 42 lesions of 20 cases of multiple gastric carcinoma, the c-Ki-ras oncogene was examined to investigate the characteristics of that carcinoma caused from gastric mucosa. A point mutation at c-Ki-ras was observed in 7 (35%) of 20 cases of multiple gastric carcinoma. The mutation ratio was statistically significantly higher than that of single gastric carcinoma, in which the point mutation was found in 6 (10.7%) of 56 cases. The mutation rate in 42 lesions of 20 cases of multiple gastric carcinoma was significantly higher in the main lesions (35.0%) than in the sublesions (9.1%). The point mutation was more found having more malignant potential cases example for in multiple gastric carcinoma than single gastric carcinoma, advanced case than early case, main lesion than sublesion, so point mutation might be showing its malignant potential. In cases showing the c-Ki-ras mutation in the sublesions of multiple gastric carcinomas, types of c-Ki-ras mutations that differed from those in the main lesions were found. Therefore, it was suggested that observation of the c-Ki-ras mutation type may be helpful in judging metastasis and infiltration in multiple gastric carcinoma lesions.

Key words
c-Ki-ras oncogene, multiple gastric carcinoma, gastric carcinoma, gastric adenoma

Reprint requests
Kazuaki Kido Second Department of Surgery, School of Medicine, Fukuoka University
7-45-1 Nanakuma, Jyounan-ku, Fukuoka-shi, 814-01 JAPAN

Accepted
July 7, 1993

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