Hepatic Resection in a Patient with Hemophilia A -A Protocol for Supplementation of Factor VIII Concentrate-

Nobuharu Yanabu, Keiichiro Mori, Yasuo Wada, Hajime Nakamura, Yoshio Yamaoka, Kazue Ozawa, Hiroshi Ohara*

Second Department of Surgery, Faculty of Medicine, Kyoto University
*Department of Surgery, Taijukai Kaisei Hospital

We performed a successful right lobectomy of the liver in a hemophilia A patient with hepatocellular carcinoma under supplementation of factor VIII concentrate. We administered 2500 units of factor VIII concentrate one hour prior to surgery. The intraoperative course was uneventful except for oozing from the abdominal wall near the end of the operation. This was controlled by an additional 2500 units of factor VIII concentrate. Since blood coagulation factorts including factor VIII are consumed more extensively in major hepatic resection than other kinds of abdominal surgery, supplementation of a lager amount of factor VIII concentrate may be necessary in the intra- and postoperative management of hepatic surgery in hemophilia patients.

Key words
hepatocellular carcinoma, hemophilia A, hepatectomy

Reprint requests
Nobuharu Yanabu Second Department of Surgery, Faculty of Medicine, Kyoto University
54 Kawaracho, Shogoin, Sakyo, Kyoot, 606 JAPAN

Accepted
September 8, 1993

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