Digestive Functions and Secretion of Gastrointestinal Hormones after Duodenum Preserving Pancreas Head Resection

Nobuhiko Harada

Department of Surgery, The Institute of Gastroenterology, Tokyo Women's Medical College

Postoperative digestive functions and secretion of gastrointestinal hormones were studied in 15 patients with duodenum preserving pancreas head resection (DpPHR) in comparison with those in 14 patients who had pylorus preserving pancreaticoduodenectomy (PpPD) reconstructed by gastro-pancreatico choledocho-jejunostomy. Postoperative integrated integrated secretion of secretin two hours after taking the test meal was 9.0±1.5 ng-min/ml in patients with DpPHR, higher than that in patients with PpPD (7.5±0.8 ng-min/ml). Pancreatic function one year after the operation decreased to 64% of the level on the preoperative value in patients with PpPD, but was preserved in patients with DpPHR (88%). No significant difference, however, was noted in postoperative evaluation of gastrin secretion after taking the test meal or in gastric acid secretion. These data show that DpPHR can preserve pancreatic exocrine function at the late postoperative period better than PpPD.

Key words
pancreas head resection reserving duodenum, pylorus preserving pancreaticoduodenectomy, postoperative digestive function, secretion of gastrointestinal hormones

Reprint requests
Nobuhiko Harada Department of Surgery, The Institute of Gastroenterology, Tokyo Women's Medical College
8-1 Kawada-cho, Shinjuku-ku, Tokyo 162 JAPAN

Accepted
November 1, 1993

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