Study of Relationship between Neural Cell Adhesion Molecule and Deleted in Colorectal Carcinomas Gene in Recurrence and Metastasis of Colorectal Cancer, and between Hepatic Metastasis of Colorectal Cancer and a Soluble form of Intercellular Adhesion Molecule 1 in Serum

Yoshihiko Hiramoto

First Department of Surgery, Okayama University Medical School (Director: Prof. Kunzo Orita)

Estimation of the recurrent form is a significant determinant factor in the prognosis of a colorectal cancer. We examined the relationship between NCAM, concerning the neural invasiveness of rectal cancers, and the DCC gene which has high homology with NCAM. We examined the relationship between hepatic metastasis of a colorectal cancer and a soluble form of ICAM-1 in serum. NCAM expression was positive in 52 colorectal cancer cases (41%) out of a total of 128 cases, but this NCAM expression was found not to be related to the histological stage of a colorectal cancer. The neural invasiveness of rectal cancers is not related to the clinicopathological factors but is significantly related to NCAM expression. While NCAM expression is not significantly related to DCC gene expression, cases with hepatic metastases tended to be NCAM negative-DCC decreased and those with local recurrence tended to be NCAM strongly positive-DCC unchanged. The DCC gene mutation is significantly related to lymph node metastasis. Cases with hepatic metastases tended to be over 700 ng/ml of a soluble form of ICAM-1 in sera. The investigation of NCAM expression in tissue and measurement of a soluble form of ICAM-1 in a colorectal cancer are suggested to be an important index for selecting appropriate postoperative therapy.

Key words
neural cell adhesion molecule, deleted in colorectal carcinoma, neural invasion of rectal cancer, local recurrence and distant metastasis in colorectal cancer, intercellular adhesion molecule-1

Reprint requests
Yoshihiko Hiramoto First Department of Surgery, Okayama University Medical School
2-5-1 Shikata-cho, Okayama, 700 JAPAN

Accepted
March 8, 1995

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