Experimental Study on the Prevention of Reperfusion Injury after Hepatic Ischemia by Hepatic Low-Temperature Perfusion

Yoshiaki Asami

Department of Surgery, Tokyo Women's Medical College, Daini Hospital

We carried out an experimental study on changes in hepatic blood circulation and hepatic oxygen supply after release of interruption of hepatic low-temperature perfusion with interruption of hepatic circulation. Adult mongrel dogs with 60 minutes' liver ischemia were divided into a hepatic lowtemperature perfusion group (n=10) and a non-perfusion group (n=8) . On and after 30 minutes after release of interruption, the hepatic artery blood flow and portal vein blood flow decreased in the non-perfusion group but increased in the perfusion group with significant differences (p<0.01). On and after 30 minutes after release of interruption, the hepatic oxygen supply decreased in the non-perfusion group, reflecting a decrease in the hepatic blood flow, but increased in the perfusion group with a significant difference (p<0.01). On and after 30 minutes after release of interruption, the oxygen consumption did not increase in the non-perfusion group but increased in the perfusion group with a significant difference (30 and 60 minutes after release, p<0.01; after 120 minutes, p<0.05) . These results suggest that hepatic low-temperature perfusion with interruption of hepatic blood circulaction increases the hepatic oxygen supply with an increase in hepatic blood flow after release of interruption, contributing to recovery from reperfusion injury resulting from hepatic warm ischemia.

Key words
hepatic low-temperature perfusion, hepatic hemodynamics, hepatic oxygen metabolism, hepatic surery with interruption of hepatic blood circulation, reperfusion injury after hepatic ischemia

Reprint requests
Yoshiaki Asami Department of Surgery, Tokyo Women's Medical College, Daini Hospital
2-1-10 Nishi-oku, Arakawa-ku, Tokyo, 116 JAPAN

Accepted
April 5, 1995

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