An Experimental Study on Effect of Upper Abdominal Autonomic Denervation and Truncal Vagotomy on Visceral Blood Flow and Portal VIP Concentration

Takashi Hashimoto

First Department of Surgery, Yamaguchi University School of Medicine

The effect of autonomic denervation and/or truncal vagotomy on visceral blood flow was studied with 15 dogs. The tissue blood flow in the duodenum, jejunum, and pancreas was measured by the hydrogen gas clearanace method. Blood flow of the portal vein was measured with an ultrasonic transit-time blood flow meter. The vasoactive intestinal polypeptide (VIP) concentration in the portal vein was also measured by the radioimmunoassay double antibody method. In the group receiving dissection of the celiac and cranial mesenteric plexus, postoperative diarrhea occurred. The blood flow in the duodenum, jejunum and portal vein decreased, while the pancreatic blood flow and portal VIP concentration increased after surgery. In the group receiving truncal vagotomy, diarrhea did not occur after truncal vagotomy. There was no significant blood flow change in the doudenum and jejunum after truncal vagotomy, whereas the blood flow in the pancreas and portal vein decreased. The portal VIP concentration increased slightly after surgery. These findings suggest that the upper abdominal autonomic denervation produced the diarrhea and significant change in visceral blood flow.

Key words
upper abdominal autonomic denervation, postoperative diarrhea, visceral blood flow, portal VIP concentration

Reprint requests
Takashi Hashimoto Fitst Department of Surgery, Yamaguchi University School of Medicine
1144 Kogushi, Ube, 755 JAPAN

Accepted
December 6, 1995

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