Undifferentiated Carcinoma with Lymphoid Stroma of the Esophagus -Report of a Case-

Kazushige Kanki, Yutaka Yoshizumi, Yoshihisa Morisaki, Yoshiaki Sugiura, Seiichi Tamai*, Shinsuke Aida*, Shingo Shima**, Susumu Tanaka

Department of Surgery II and Department of Lablolatory Medicine*, National Defense Medical College
Department of Surgery, The Second Tokyo National Hospital**

A case of non-small cell undifferentiated carcinoma with lymphoid stroma of the esophagus in a 75-year-old woman is described. The chief presenting complaint was dysphagia. Biopsy revealed undifferentiated carcinoma. Surgery was performed after chemotherapy with intravenous CDDP at 80 mg/m². In the surgical specimen, most of the tumor was covered with normal mucosa, as in submucosal tumors. Microscopic observation revealed proliferation of relatively large malignant cells with marked lymphoid infiltration, predominantly of T-cells. The pathological diagnosis of the tumor was made as undifferentiated carcinoma since there was no finding of sequamous or glandular differentiation, histologic stage a2n4, stage IV. One year and l0 months later, a recurrent tumor in a cervical lymph node was resected. The prognosis of undifferentiated carcinoma of the esophagus is generally recognized as poor but some cases with lymphoid stroma have been reported to have a favorable prognosis. In this case, the prognosis was relatively favorable in spite of the advanced stage, and the patient is doing well 3 years and 5 months after esophagectomy. This is the 5th report in Japan of carcinoma of the esophagus with lymphoid stroma.

Key words
undifferentiated carcinoma, esophagus, lymphoid stroma

Reprint requests
Kazushige Kanki Department of Surgery II, National Defense Medical College
3-2 Namiki, Tokorozawa, 359 JAPAN

Accepted
November 13, 1996

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