Clinical Studies on the Relationship between Rapid Turnover Protein and Host Immunity in the Perioperative Patients with Gastric Cancer

Naohiro Washizawa

First Department of Surgery, Toho University School of Medicine

In order to clarify the relationship between the nutritonal state and the host nonspecific immunity in the 31 patients who had undergone surgery for stage I_a, I_b, II gastric cancer, we studied the correlations between various nutritional parameters, especially albumin (Alb), the rapid turnover proteins (RTP: transferrin, prealbumin, retinol binding protein), and immunological parameters. At the 2nd postoperative week, there were significant positive correlations between each RTP-concentrations and the proportions of CD11b(+)CD8 dull(+)cells and CD16(+)CD57(-)cells. On the other hand, when the changes in Alb·RTP after gastrectomy were investigated, it was found that, at the first and second weeks after, the recovery of Alb and RTP levels were correlated with CD4(+)CD45RA(-)cell, CDl1b(+)CD8 dull(+)cell proportion. These results suggest that the levels of RTPs are useful parameters for the perioperative patients on account of correlating with the immunofunction.

Key words
perioperative patients with gastric cancer, albumin, rapid turnover protein, nonspecific immunological parameters

Reprint requests
Naohiro Washizawa First Department of Surgery, Toho University School of Medicine JAPAN

Accepted
April 23, 1997

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