A Case of Peutz-Jeghers Syndrome Associated with Advanced Jejunal Cancer

Hideaki Mabuchi, Kanji Nishiguchi, Eiji Nakata*, Masayuki Ohta*, Hitoshi Inoue*, Shinichiro Kodama*, Nobuhiko Tanigawa

Department of General and Gastroenterological Surgery, Osaka Medical College
*Ohtori Icho Hospital

We report a case of Peutz-Jeghers Syndrome associated with advanced jejunal cancer. A 43-year-old man was diagnosed as having Peutz-Jeghers Syndrome. He was referred to the hospital because of ileus which was pointed out at a nearby clinic. Further gastrointestinal examinations revealed multiple polyps in the stomach, small intestine, and colon. An operation was performed because there were repeated episodes of ileus symptoms. At laparotomy, a jejunal cancer which caused narrowing of the entire circumference with peritoneal dissemination was found, and histopathologically the tumor was mucinous adenocarcinoma. Possible association of the polypoid lesions with cancer could not be speculated on in this case, because the cancer was far advanced. The number of reports that have suggested a malignant change in polyps of this syndrome has recently increased. Further studies would be required to clarify the mechanism of malignant formation in the polypoid lesions. In addition, careful clinical follow-up is recommended considering an association with cancer whenever we encounter patients with this sydrome.

Key words
Peutz-Jeghers Syndrome, advanced jejunal cancer

Reprint requests
Hideaki Mabuchi Department of General and Gastroenterological Surgery, Osaka Medical College
2-7 Daigakumachi, Takatsuki, 569-8686 JAPAN

Accepted
July 22, 1998

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