A Case Report of Granulocyte-Colony Stimulating FactorProducing So-called Carcinosarcoma of Esophagus

Takafumi Oshiro, Hiroshi Yahata, Naoki Haruta, Hidehiro Tanji, Katsunori Shinozaki, Kazunori Uchida, Keizou Sugino, Seiji Marubayashi, Toshimasa Asahara and Kiyohiko Dohi

The Second Department of Surgery, Hiroshima University School of Medicine

A 56-year-old mas who complained of dysphagia was admitted to our hospital. The patient was diagnosed as having an esophageal carcinoma with leukocytosis (19,400/mm³). A subtotal esophagectomy was done on June 9,1998. Histopathological examination revealed a so-called carcinosarcoma of mp, n (-), Pl₀, M₀ and stage I. Postoperatively, the leukocyte count decreased rapidly. Preoperative serum granulocyte-colony stimulating factor (G-CSF) level was 109 pg/ml, and postoperative serum G-CSF levels on 72POD and 195POD were 21 pg/ml and 11 pg/ml. An immunohistochemical study showed positive staining for G-CSF in the tumor cell. G-CSF producing esophageal so-called carcinosarcoma is very rare and only one case has been reported in Japan. Although the reports indicate poor prognosis for G-CSF producing tumors, postoperative recurrence has not been detected in this case for 8 months.

Key words
granulocyte-colony stimulating factor, so-called carcinosarcoma of esophagus

Reprint requests
Takafumi Oshiro Second Department of Surgery, Hiroshima University 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551 JAPAN

Accepted
April 28, 1999

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