A Case of Gastric Endocrine Cell Carcinoma with Extramural Growth

Masayuki Kitajima, Ken Ono, Takeshi Takada, Eiichiro Seki, Yuichi Tomiki, Yasuo Hayashida, Toshiki Kamano, Masahiko Tsurumaru, Masaru Takase^* and Toshiharu Matsumoto^*

1st Department of Surgery, Juntendo University, School of Medicine ^*Department of Pathology, Juntendo University, School of Medicine

A 55-year-old man came to our hospital because of a mass in the left upper quadrant of the abdomen. Gastroscopy showed a huge submucosal tumor with two ulcers in the posterior wall of the middle of the stomach. A preoperative diagnosis of type 5'gastric cancer in the middle of the gastric body was made, and total gastrectomy with combined resection of the gallbladder, spleen, and transverse colon was performed. Histopathological examination showed small cells with round or short spindle-shaped nuclei, aligned in a cord arrangement to form a pseudo-rosette. NSE staining, Grimelius staining and chromogranin A staining were positive. The tumor was diagnosed as gastric endocrine cell carcinoma. Gastric endocrine cell carcinoma is very rare and reported to account for 0.06% to 0.08% of gastric carcinomas.

Key words
endocrine cell carcinoma, extramural growth

Reprint requests
Masayuki Kitajima 1st Department of Surgery, Juntendo University, School of Medicine 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421 JAPAN

Accepted
July 25, 2000

To read the PDF file you will need Abobe Reader installed on your computer.