A Study of Treatment for Extrahepatic Metastasis after Sugical Treatment of Hepatocellular Carcinoma

Kazuhiko Sakamoto, Kimihiro Nakashima, Shinichiro Migo, Keitaro Hasuda and Hideaki Anai

Department of Surgery, National Oita Hospital

From 1996 to 2000, 105 patients with hepatocellular carcinoma (HCC) underwent inital surgical treatment (hepatectomy in 62 and ablation in 43) at our institute. Twelve of the 105 suffered extrahepatic metastasis. Nine of the12had intrahepatic metastasis, and 6 were controlled by various treatment to liver (TAE, CAI, MCT, RFA and resection). Metastatic sites of the 12 with multiple organ recurrence were lung (7), peritoneum (5), lymph node (4), adrenal gland (3), bone (1), brain (1), and stomach (1). These extrahepatic lesions were treated by resection in15, systemic chemotherapy in6, and radiation in 3 (overlapping occurred). The1-year survival of the12 was 67% and 3-year survival was 39%. The 3-year survival of those with resected extrahepatic metastasis (69%, n=7) was significantly better than that of unresected (0%, n=5, p=0.0045). In those with resected extrahepatic metastasis, intrahepatic recurrence was controlled of all. These results suggest that extrahepatic HCC metastasis should be resected if the lesion is completely resectable and intrahepatic recurrence is controlled.

Key words
hepatocellular carcinoma, resection of extrahepatic metastasis

Reprint requests
Kazuhiko Sakamoto Department of Surgery, National Oita Hospital 2-11-15, Yokota, Oita, 870-0263 JAPAN

Accepted
September 19, 2001

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