Synchronous Occurrence of Gastrointestinal Stromal Tumor in the Stomach and Duodenum after Mastectomy for Breast Cancer: A Case Report

Kenju Ko, Yukihiko Akita, Eiji Chikamatsu, Masafumi Menjo and Masaya Shiomi

Department of Surgery, Gifu Social Insurance Hospital

A 74-year-old woman was found in gastric endoscopy and upper gastrointestinal studies to have a gastrointestinal stromal tumor (GIST) of the stomach and duodenum. She underwent mastectomy for breast cancer about 3 years earlier and had neither symptoms nor recurrence. The submucosal tumor occupied the fundus of the stomach and bulbus of the duodenum with vascular hyperplasia. Under a diagnosis of leimyoma or leiomyosarcoma, we conducted partial gastrectomy for the gastric tumor and partial gastrodudenectomy for the duodenal tumor. Immunohistochemical studies of the resected stomach showed tumor cells were positive for CD-34, c-kit, vimentin, and neuron-specific enolase (NSE) but were negative for smooth muscle antigen (SMA) and s-100. The resected duodenum showed tumor cells positive for c-kit and vimentin, but negative for CD34, NSE, SMA, and s-100. Although both tumors were diagnosed as GIST, they were not regarded to have the same origin. A gastrointestinal stromal tumors rarely develop simultaneously in both the stomach and duodenum.

Key words
gastrointestinal stromal tumor, stomach and duodenum, synchronous occurrence

Reprint requests
Kenju Ko Department of Surgery, Gifu Social Insurance Hospital 1221-5, Dota, Kani, 509-0206 JAPAN

Accepted
May 1, 2002

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