A Case of Colon Cancer with Congenital Factor V Deficiency

Yoshifumi Sakata, Hideo Mishima, Kazuya Yamaguchi and Naoki Hirabayashi

Department of Gastroenterology, Hannan Municipal Hospital

A 71-year-old woman seen for anemia and positive fecal occult blood, was found in Barium enema examination and colonoscopy to have colon cancer at the hepatic flexure. Preoperative screening showed anemia, prolonged prothrombin time (PT) (22.8 s 23.5%), and activated partial thromboplastin time (APTT) (58.1 s). The level of the factor V was 9%. Her parents had a consanguineous marriage. We found the patient had congenital factor V deficiency (parahemophilia), so we transfused 6 units of fresh frozen plasma (FFP) preoperatively to improve PT and APTT. Under transfusion of FFP, we conducted right hemicolectomy. We transfused 20 units of FFP postoperatively. No serious hemorrhaging was detected during or after surgery.

Key words
congenital factor V deficiency, parahemophilia, colon cancer

Reprint requests
Yoshifumi Sakata Department of Surgery, Kainan Municipal Hospital 1272-3 Hikata, Kainan, 642-0002 JAPAN

Accepted
May 27, 2003

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