CASE REPORT
Two Cases of Duodenal Somatostatinoma Associated with von Recklinghausen's Disease
Naoto Katagata, Mutsuo Yamada, Kenzi Gonda, Takeshi Sakuma, Fumiaki Watanabe, Tadashi Nomizu, Yoshiko Yamaguchi1) and Mitsuhiro Nihei2)
Department of Surgery and Department of Pathology1), Hoshi General Hospital
Igarashi Internal and Surgical Clinic2)
We report two cases of duodenal somatostatinoma associated with von Recklinghausen's disease. Case 1 involved a 45-year-old man and case 2 a 67-year-old man, in whom cafe-aulait skin macules and multiple neurofibromas were noted over the entire body. They underwent pancreatoduodenectomy based on a diagnosis of duodenal carcinoid in the oral side of the papilla of Vater. Histologically, the duodenal tumors in these cases infiltrated the pancreatic head. A high-power view showed tumors to consist of small round cells with a solid or trabecular pattern and conspicuous psammoma bodies. Regional lymph nodes contained metastases. Immunohistochemical examination showed that tumor cells stained for somatostatin and chromogranin. In case 1, ultrastractual study demonstrated neuroendocrine secretory granules (300-400 nm in diameter) in cytoplasm.It is noted that somatostatinoma should be considered on differential diagnosis in patient with von Recklinghausen's disease accompanied with periampullary neoplasm.
Key words
somatostatinoma, neurofibromatosis, duodenum
Jpn J Gastroenterol Surg 38: 1312-1317, 2005
Reprint requests
Naoto Katagata Department of Surgery, Hoshi General Hospital
2-1-16 Omachi, Koriyama, 963-8501 JAPAN
Accepted
February 23, 2005
|
To read the PDF file you will need Abobe Reader installed on your computer. |
|