A Case of Multiple Early Colon Cancers Associated with Japanese Schistosomimasis

Akihisa Matsuda, Masayoshi Hashimoto, Sohtaro Kuwana¹⁾, Susumu Yamakado¹⁾, Nobue Ueki¹⁾, Kiyonori Furukawa²⁾ and Takashi Tajiri²⁾

Department of Surgery and Department of Internal Medicine¹⁾, Mitsubishi Heavy Industries Ohkurayama Hospital
Surgery for Organ Function and Biological Regulation, Nippon Medical School, Graduate School of Medicine²⁾

We report a case of multiple early colon cancers associated with Japanese Schistosomiasis. A 85-year-old woman treated for hypertension and diabetes mellitus and reporting melena was found in barium enema and colonoscopic examination to have a sigmoid colon tumor and multiple ascending colon polyps, necessitating sigmoidectomy and mucosal resection of the ascending colon. Pathological findings showed the sigmoid colon tumor to be moderately differentiated adenocarcinoma in tubulovillous adenoma and ascending colon polyps with two tubular adenomas and one moderately differentiated adenocarcinoma in tubular adenoma. We found innumerable ova of Japanese Schistosomiasis centering around the submucosal layer of the resected specimen. We discuss the correlation between interposing ova of Japanese Schistosomiasis and the development of colon caner.

Key words
Japanese Schistosomiasis, colon cancer, oncogenesis

Reprint requests
Akihisa Matsuda Surgery for Organ Function and Biological Regulation, Nippon Medical School, Graduate School of Medicine
1-1-5 Sendagi, Bunkyo-ku, 113-8603

Accepted
May 25, 2005

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