Two Cases of Resected Hepatocellular Carcinoma with Non-Viral Autoimmune Hepatitis

Toshiro Masuda, Toru Beppu, Takatoshi Ishiko, Shinichi Sugiyama, Hiroshi Takamori, Keiichiro Kanemitsu, Masahiko Hirota, Ryo Takaoka*, Motohiko Tanaka* and Hideo Baba

Department of Gastroenterological Surgery and Department of Gastroenterology and Hepatology*, Graduate School of Medical Sciences, Kumamoto University

We report two cases of resected hepatocellular carcinoma (HCC) with nonviral autoimmune hepatitis (AIH). Case 1: A 36-year-old woman treated for AIH for 23 years with predonisolone underwent partial hepatectomy for HCC. The tumor was 4.8 cm in diameter, and involved moderate to poorly differentiated HCC surrounded by well differentiated HCC. The non cancerous lesion showed chronic hepatitis. HBV-DNA and HCV-RNA were negative in serum. Case 2: A 68-year-old woman treated for AIH for 20 years with PSL underwent systematic hepatectomy for HCC. The tumor was 2.5 cm in diameter, and histologically involved moderately differentiated HCC. The non cancerous lesion showed chronic hepatitis. HBV-DNA and HCV-RNA were negative in liver tissue and serum. It is supposed that HCC in AIH is caused by liver cirrhosis, long-term administration of steroids, or association of chronic viral hepatitis. It is necessary to check them. The non cancerous lesions in both cases showed chronic hepatitis. Both women had been treated for AIH with PSL for long periods, and had little relation to HBV or HCV.

Key words
hepatocellular carcinoma, autoimmune hepatitis, hepatic resection

Reprint requests
Toshiro Masuda Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University
1-1-1 Honjo, Kumamoto, 860-8556 JAPAN

Accepted
September 27, 2006

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