A Case of Extramedullary Plasmacytoma of the Stomach

Nagato Sato¹⁾²⁾, Yasuhiro Suzuki¹⁾, Ryou Takahashi¹⁾²⁾, Hiroyuki Hashimoto¹⁾²⁾, Kenjiro Misu¹⁾²⁾, Motoo Takahashi¹⁾ and Satoshi Kondo²⁾

Department of Surgery, Shinnittetsu Muroran General Hospital¹⁾
Surgical Oncology, Division of Cancer Medicine, Hokkaido University Graduate School of Medicine²⁾

A 62-year-old man referred for bloody stool due to sigmoid colon cancer was found in endoscopy to have granular changes in the mucosa at the upper gastric antrum. Biopsy yielded a diagnosis of extramedullatory plasmacytoma of the stomach. Positron emission tomography with 16F-fluoro-2-deoxy-D-glucose (FDG-PET) identified tumors in the stomach and colon necessitating total gastorectomy and sigmoidectomy. Macroscopic examination showed granular changes with mucosal thickening. Pathological findings showed diffuse proliferation of plasma cells limited to the lamina propria mucosae and no lymph metastasis. Immunochemically, IgA and κ were positive. The colon tumor was diagnosed as well-differentiated adenocarcinoma. He has remained disease-free during 6 months of follow-up.

Key words
extramedullatory plasmacytoma, stomach, positron emission tomography with 16F-fluoro-2-deoxy-D-glucose (FDG-PET)

Reprint requests
Nagato Sato Laboratory of Molecular Medicine, Human Genome Center Institute of Medical Science, the University of Tokyo
4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639 JAPAN

Accepted
September 27, 2006

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