A Case of Adenoid Cystic Carcinoma of the Esophagus -with Reference to Immunohistochemical Study-

Hiromichi Ishii, Hiroshi Sato, Yasuhiro Tsubosa, Hiroto Ishiki* and Kimihide Hukakusa*

Division of Esophageal Surgery and Division of Pathology*, Shizuoka Cancer Center Hospital

We report a case of adenoid cystic carcinoma (ACC) of the esophagus determined immunohistochemically. A 51-year-old man with an ulcerative localized esophageal tumor that stained with iodine dyeing was found from the biopsy specimen in preoperative endoscopy to have ACC. He underwent subtotal esophagectomy with two-field lymph node dissection. Histopathologic findings showed pure ACC of the esophagus. Immunohistochemically, tumor cells stained positively for EMA, αSMA, and vimentin, similar to ACC of the salivary gland. Immunohistocemical examination was thus useful in distinguishing between ACC and basaloid squamous carcinoma of the esophagus. This tumor was not biologically aggressive in light of cell proliferation because the MIB-1 labeling index was 5%, similar to ACC of the salivary grand.

Key words
adenoid cystic carcinoma of the esophagus, immunohistochemical study, MIB-1 labeling index

Reprint requests
Hiromichi Ishii Division of Esophageal Surgery, Shizuoka Cancer Center Hospital
1007 Shimo-Nagakubo, Sunto-Nagaizumi, 411-8777 JAPAN

Accepted
October 25, 2006

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