A Case of Adenosquamous Carcinoma of the Extrahepatic Bile Duct

Yoshiki Naito, Koichi Higaki¹⁾, Masaya Tanaka²⁾, Satoshi Taniwaki²⁾ and Masamichi Kojiro

Department of Pathology, Kurume University School of Medicine
Departments of Pathology¹⁾ and Department of Surgery²⁾, St. Mary's Hospital

A 77-year-old-woman admitted for jaundice and cutaneous itching was found in abdominal computed tomography (CT) and PTBD to have a polypoid lesion in the common bile duct confirmed by cholic cytology to be adenocarcinoma. Pancreatoduodenectomy was conducted under the diagnosis of carcinoma of the extrahepatic bile duct. The tumor consisted of an admixture of poorly differentiated adenocarcinoma and squamous cell carcinoma and was definitively diagnosed as adenosquamous carcinoma of the extrahepatic bile duct. Immunohistochemically, CAM5.2 was expressed in the adenocarcinoma component and 34βE12 in the squamous cell carcinoma component. For proliferative activity, the Ki-67 labeling index was about 70% in both components.

Key words
carcinoma of the extrahepatic bile duct, adenosquamous carcinoma

Reprint requests
Yoshiki Naito Department of Pathology, Kurume University School of Medicine
67 Asahimachi, Kurume, 830-0011 JAPAN

Accepted
October 25, 2006

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