A Case of Splenic Marginal Zone Lymphoma

Yoshiki Naito, Toru kume¹⁾, Masayasu Naito¹⁾, Michitoshi Hashiguchi²⁾, Takashi Okamura²⁾, Naofumi Eriguchi³⁾, Hisanori Naito³⁾, Koichi Ohshima and Hirohisa Yano

Department of Pathology, Kurume University School of Medicine
Depertment of Gastroenterological Surgery, Fukuoka University School of Medicine¹⁾
Division of Hematology, Department of Internal medicine, Kurume University School of Medicine²⁾
Naito Hospital³⁾

A 64-year-old seen for fever and lower left back pain and having a 4-year history of chronic hepatitis B was found in abdominal CT to have an intrasplenic tumor and FDG-PET showed abnormal uptake in the spleen. Since these findings suggested primary malignant lymphoma of the spleen, we conducted splenectomy with pancreatic tail resection for histological diagnosis and tumor reduction. Macroscopically, the spleen was 19×15 cm, with multiple nodules. Histopathological examination of tumor cells showed medium-sized, abundant pale cytoplasm. The definitive diagnosed Primary malignant lymphoma of the spleen with splenic marginal zone lymphoma. Since generalized lymphadenopathy develops early after surgery, the patient was admitted in an emergency and THP-COP was started on the same day. Systemic symptoms subsequently were reduced, and FDG-PET showed no abnormal uptake in general lymph nodes. As of postoperative 13 months, the patient has followed regularly.

Key words
malignant lymphoma, splenic marginal zone lymphoma, HB virus

Reprint requests
Yoshiki Naito Department of Pathology, Kurume University School of Medicine
67 Asahi-machi, Kurume, 830-0011 JAPAN

Accepted
July 25, 2007

To read the PDF file you will need Abobe Reader installed on your computer.