A Case of Familial Adenomatous Polyposis with Multiple Colorectal Cancers for which DWI-MRI were Useful in Preoperative Diagnosis

Hidenori Miyamoto, Masanori Nishioka, Nobuhiro Kurita, Kouzou Yoshikawa, Jun Higashijima, Tomohiko Miyatani, Junko Honda and Mitsuo Shimada

Department of Surgery, University of Tokushima

Diffusion-weighted magnetic resonance imaging (DWI-MRI) has been used to examine the abdominal region, and tumors have been found to have increased signal intensity. We report a patient in whom DWI-MRI was useful in detecting synchronous multiple colorectal cancer. A 26-year-old woman not diagnosed familial adenomatous polyposis (FAP) had anorexia and diarrhea from June 2005. Colonoscopy showed multiple polipoid lesions of the rectum and a severe stenotic lesion of the sigmoid colon. She was diagnosed with FAP with deletion of exon 15 codon 1309 to 1311 by PCR-SSCP method and advanced sigmoid colon cancer. Although colonoscopy was incomplete because of stenosis, we detected 5 synchronous colorectal cancers by DWI-MRI and 8 synchronous colorectal cancers were detected pathologically. Our findings suggest that DWI-MRI may be useful in detecting patients with synchronous multiple colorectal cancer and with incomplete colonoscopy.

Key words
diffusion-weighted magnetic resonance imaging (DWI-MRI), preoperative diagnosis, advanced colorectal cancer

Reprint requests
Hidenori Miyamoto Department of Surgery, University of Tokushima
3-18-15 Kuramoto, Tokushima, 770-8503 JAPAN

Accepted
July 25, 2007

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