Effectiveness of Chemoradiation Therapy Against Endocrine Cell Carcinoma of the Rectum: Report of a Case

Hiroyoshi Sendo, Hideki Idei²⁾, Sachiyo Shirakawa, Tohru Nishimura, Kunihiko Kaneda, Takahiro Wada and Tomohiko Kizaki¹⁾

Department of Surgery and Department of Pathology¹⁾, Sanda Municipal Hospital
Department of Surgery, Hyogo Prefectural Himeji Cardiovascular Center²⁾

We report a case of endocrine cell carcinoma of the rectum responding to preoperative chemoradiation therapy. A 61-year-old man with unresectable advanced lower rectal carcinoma underwent a colostomy and was treated by chemotherapy with CPT-11, 5-FU, and l-LV combined with irradiation to the pelvis. The tumor subsequently shrank and radical abdominoperineal resection was done. The definitive diagnosis was endocrine cell carcinoma. We confirmed the absence of recurrence 46 months after radical surgery. Colorectal endocrine cell carcinoma is dismal and cannot treated by surgery alone. Intensive treatment including preoperative chemotherapy and radiation may be effective in fighting this disease.

Key words
endocrine cell carcinoma, rectum, chemoradiation therapy

Reprint requests
Hiroyoshi Sendo Department of Surgery, Sanda Municipal Hospital
3-1-1 Keyakidai, Sanda, 669-1321 JAPAN

Accepted
January 30, 2008

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