Two Cases of Gastric Adenocarcinomas after the Remission of Gastric Malignant Lymphoma treated by Chemo-Radiotherapy

Junpei Yamaguchi, Hitoshi Katai, Takeshi Sano, Takeo Hukagawa, Makoto Saka, Masaya Inoue, Mitsuru Sasako and Hirokazu Taniguchi*

Gastric Surgery Division and Pathology Division*, National Cancer Center Hospital

We present two cases of gastric adenocarcinoma following complete remission of malignant gastric lymphoma after chemoradiotherapy. The patients were two men, one 75 years old and 65 years old. Endoscopy showed malignant gastric lymphoma (diffuse large B cell lymphoma, stage II₁) in both, who underwent CHOP (cyclophosphamide, doxorubicin, vincristine, prednisolone) chemotherapy and radiotherapy. After complete malignant lymphoma remission (CR), upper endoscopic studies in follow-up showed gastric carcinoma, necessitating pylorus-preserving gastrectomy in one with pathological stage T1 (SM2) N0 M0 Stage IA, and total gastrectomy in the other with pathological stage T3 (SS) N2 M0 CY1 Stage IV. Both suffered distant metastasis soon after surgery. Close gastric follow-up is thus important following chemoradiation therapy, witch is reported to involve the risk of a second gastric malignancy.

Key words
gastric carcinoma, malignant lymphoma, chemoradiotherapy

Reprint requests
Hitoshi Katai Gastric Surgery Division, National Cancer Center Hospital
5-1-1 Tsukiji, Chuo-ku, 104-0045 JAPAN

Accepted
February 20, 2008

To read the PDF file you will need Abobe Reader installed on your computer.