A Resected Case of Cholangiolocellular Carcinoma during Treatment for Bladder Tumor: Report of A Case

Kentarou Hashizume, Kouji Shindou, Kei Fujii, Tomonari Sasazuki, Youhei Tominaga, Ichio Hirota, Tohru Eguchi, Shinji Kohno¹⁾ and Shinichi Aishima²⁾

Department of Surgery and Department of Pathology¹⁾, Harasanshin Hospital
Department of Anatomical Pathology, Graduate School of Medical Sciences, Kyushu University²⁾

We report a case of rare hepatic malignant primary cholangiolocellular carcinoma (CoCC). A 87-year-old man followed up after transurethral resection of a bladder tumor, was found to have a solitary hepatic tumor measuring 30 mm in diameter in an abdominal computed tomography (CT) checkup. It showed peripheral enhancement in the arterial phase and enhancement retention in the delayed phase. Preoperative echo-guided biopsy indicated moderately differentiated cholangiocarcinoma (CCC). Histological findings for the resected tumor showed small ductules similar to cholangioles proliferating in an anastomosing pattern with abundant fibrous stroma having neither HCC-like areas, nor CCC-like areas. Immunohistochemically, the tumor presented cells diffusely positive for CK7 and CK19, and negative for HepPar1. PAS and Alcian blue staining showed an absence of mucin in tumor cells. C-kit staining showed focally positive cancer cells. These findings are compatible with CoCC.

Key words
cholangiolocellular carcinoma, hepatic stem cell

Reprint requests
Kentarou Hashizume Department of Surgery, Harasanshin Hospital
1-8 Taihaku-cho, Hakata-ku, Fukuoka, 812-0033 JAPAN

Accepted
April 22, 2009

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