Analysis on the Factor of Liver Regeneration after Hepatic Resection -Relation between Liver Regeneration and the Pathological Findings of Liver Parenchyma-

Shojiro Miyazaki

Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical College (Chairman: Prof. Fujio Hanyu)

Liver regeneration after hepatic resection (the growth rate of the remnant liver) related to pathological findings of the resected liver were studied. Seventy cases of hepatic resection were used in the study. The growth rates of the remnant liver were calculated twice by computed tomography, once before and 3∼4 weeks after hepatic resection. The degrees of fibrosis, inflammatory cell infiltration, and piecemeal necrosis were determined microscopically, and divided into four groups. In the cases without fibrosis or with mild fibrosis, the growth rate of the remnant liver increased exponentially in proportion to the rates of removal of the liver (p<0.001). The regression curves of the growth rate in the mild fibrosis group were significantly lower than in the group without fibrosis. In the groups with moderate or severe fibrosis also, no significant correlation was found between the growth rates and the removal rates. Less significant differences were found between the growth rates divided by the degrees of inflammatory cell infiltration or piecemeal necrosis than between those divided by the degree of fibrosis. We concluded that the degree of fibrosis regulates the regeneration of remnant liver.

Key words
liver regeneration of remnant liver, growth rate of remnant liver, removal rate of liver, pathological findings of liver parenchyma

Reprint requests
Shojiro Miyazaki Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical College
8-1 Kawada-cho, Shinjuku, Tokyo, 162 JAPAN

Accepted
October 7, 1992

To read the PDF file you will need Abobe Reader installed on your computer.