CASE REPORT
A Case of a Granulocyte-Stimulating Factor Producing Gastric Carcinoma
Takayuki Aimoto1)2), Hatsuo Yoshida, Nobuatsu Koyama, Mitsuhiro Nihei, Mitsuaki Sakonji1), Masahiko Onda2)
1)Department of Surgery, Tsuboi Hospital 2)First Department of Surgery, Nippon Medical School
A 55-year-old man was admitted to our hospital because of anorexia. The laboratory data on admission showed marked leukocytosis (21200/mm3). Upper gastrointestinal X ray and endoscopic examination revealed a type 2 gastric cancer at the antrum of the stomach. The patient underwent distal gastrectomy with D2 lymph node dissection on October 30, 1995. Surgical stage grouping was T2, N2, P0, H0, Stage IIIa. The lesion, measuring 110×90 mm, was type 5T2 according to macroscopic classification. Pathologic findings were pap, ss, ly3, v3 and n2. From the 3rd day after the operation to the 28th day, the leukocyte count and the level of G-CSF in serum fell from 19200/mm3 to 7200/mm3 and 195 pg/ml to 60 pg/ml, respectively. The postoperative course was good. The patient was discharged from our hospital on February 20, 1996. Immunohistochemical study showed positive staining for G-CSF within the cytoplasm of the tumor cells. A diagnosis of a G-CSF-producing gastric carcinoma was made from these findings. There have been only 7 cases of a G-CSF-producing gastric carcinoma in Japan, including ours.
Key words
granulocyte-colony stimulating factor, gastric carcinoma
Jpn J Gastroenterol Surg 30: 2004-2008, 1997
Reprint requests
Takayuki Aimoto Department of Surgery, Tsuboi Hospital
1-10-13 Nagakubo, Asaka-machi, Kooriyama-shi, 963-01 JAPAN
Accepted
April 23, 1997
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