Squamous Cell Carcinoma of the Stomach with Multiple Liver Metastases: A Case Report

Tomoaki Maruta, Shigeki Nakamura^*, Kanji Shimada^*, Hiroshi Kaneko^** and Katsuyoshi Hatakeyama

The First Department of Surgery, Niigata University School of Medicine, Department of Surgery, Niigata Prefectural Kamo Hospital^*, Department of Pathology, Falco Biosystems Kanetsu^**

We report a case of squamous cell carcinoma of stomach with multiple liver metastases. The patient was a 65-year-old woman with epigastralgia and appetite loss. Gastric cancer in the upper body of the stomach and multiple liver metastases were diagnosed. Total gastrectomy and perigastric lymph node dissection with caudal pancreatectomy and splenectomy were performed. Mitomycin C and fluorouracil were infused through the hepatic artery with a subcutaneous reservoir. The histological examination demonstrated squamous cell carcinoma. There was no evidence of adenocarcinoma in the main tumor. However, a few of the lymph node metastases showed adenocarcinoma. The pathogenesis of squamous cell carcinoma of the stomach might be squamous differentiation in a pre-existing adenocarcinoma. Liver metastases were reduced by hepatic arterial infusion. The patient is doing well 33 months after operation.

Key words
squamous cell carcinoma of stomach, hepatic arterial infusion, multiple liver metastases

Reprint requests
Tomoaki Maruta First Department of Surgery, Niigata University School of Medicine 1-757 Asahimachi-dori, Niigata-City, 951-8510 JAPAN

Accepted
April 25, 2001

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