A Case of HTLV-1 Associated Primary Gastric Lymphoma

Nobuhiro Ito, Kazuyoshi Suzumura*, Takashi Arikawa, Ichiro Horikoshi, Katsuhiro Kotake, Hitoshi Inagaki, Yosihiro Oowa, Hiroshi Nagata, Tsuyoshi Kurokawa and Toshiaki Nonami

Department of Gastroenterological Surgery, Department of Genaral Surgery*, Aichi Medical University

We reported a rare case of HTLV-1-associated primary gastric lymphoma. A 65-year-old man admitted for epigastric discomfort was found in endoscopic examination and an upper gastrointestinal series to have an irregular elevated lesion in the middle third of the stomach, and histological study showed T-cell type lymphoma. Anti-HTLV-1 antibody was positive in serum. CT and galium scintigraphy showed no lymph node swelling or metastasis to other organs. We conducted total gastrectomy, splenectomy, and cholecystectomy with D2 lymph node dissection. HTLV-1 pro-viral DNA was positive in the resected specimen, but negative in bone marrow. Abnormal lymphocytes were negative in peripheral blood and bone marrow. We diagnosed this as a case of HTLV-1-associated primary gastric lymphoma, a very rare occurrence with no treatment strategy yet established. Further accumulation of cases should help solve this problem.

Key words
HTLV-1 associated primary gastric lymphoma, HTLV-1 pro-viral DNA

Reprint requests
Nobuhiro Ito Department of Gastroenterological Surgery, Aichi Medical University
21 Karimata, Yazako, Nagakute-cho, Aichi, 480-1195 JAPAN

Accepted
October 29, 2003

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