A Case of Gastric Granular Cell Tumor that was completely resected en Bloc by Laparoscopy-Assisted Partial Gastrectomy

Nobue Futawatari, Shinichi Sakuramoto, Hiromitsu Moriya, Natsuya Katada, Shiro Kikuchi, Masahiko Watanabe and Atsuko Hara*

Department of Surgery and Department of Pathology*, School of Medicine, Kitasato University

We report a case of gastric granular cell tumor that was completely resected en bloc by laparoscopy-assisted partial gastrectomy. A 56-year-old man seen for a stomach tumor found 1 year earlier in a medical checkup was found in upper gastrointestinal endoscopy to have a 25-mm submucosal tumor growing inside the upper lesser gastric curvature. The tumor grew to 30 mm within 10 months, necessitating ultrasonography. The diagnosis was a 36 mm submucosal tumor originating in the fourth layer. Fine-needle aspiration biopsy done under endoscopic ultrasonography yielded a diagnosis of gastrointestinal stromal tumor (GIST). Abdominal ultrasonography and computed tomography did not show metastasis and the patient was scheduled to undergo surgery. The postoperative course following laparoscopy-assisted partial gastrectomy was favorable, and the man was discharged 8 days after surgery. Histopathological analysis showed the neoplasm to be a 4.5×3.5×3.5 cm submucosal tumor. Histological analysis revealed tumor cells with eosinophilic cytoplasm that proliferated by forming large and small lesions, and immunological staining detected S-100 and synaptophysin, but no KIT, CD34, smooth muscle actin, or epithelial markers. The definitive diagnosis was a granular cell tumor.

Key words
granular cell tumor, laparoscopic surgery, gastric submucosal tumor

Reprint requests
Nobue Futawatari Department of Surgery, School of Medicine, Kitasato University
2-1-1 Asamizodai, Sagamihara, 228-8520 JAPAN

Accepted
January 28, 2009

To read the PDF file you will need Abobe Reader installed on your computer.