Pathology of Hepatolithiasis

Yasuni Nakanuma

Second Department of Pathology, Kanazawa University School of Medicine

Our recent study disclosed peribiliary glands around the large intrahepatic biliary tree. These were divided into intramural and extramural glands. The latter appeared as tree-like projections on biliary casts. A national survey on hepatolithiasis disclosed that this disease was largely divided into common type (bilirubin calcium stones, unknown etiology) and special type. The majority of cases of hepatolithiasis (226 of the 237 casees) were of the former type, and stone-containing bile ducts showed fibrosis, glandular proliferation, and many inflammatory cells (chronic proliferative cholangitis). The latter was uncommon (48 cases) and consisted of 8 subgroups, such as hepatolithiasis associated with malformation or intrahepatic cholesterol stones.

Key words
biliary tree, peribiliary glands, hepatolithiasis

Reprint requests
Yasuni Nakanuma Second Department of Pathology, Kanazawa University School of Medicine
13-1 Takara-machi, Kanazawa, 920 JAPAN

Accepted
September 19, 1989

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