An Experimental Study of the Ileo-Jejunal Transposition on the Influence of Canine Gastric Acid Secretion and Gut Hormones

Morihiko Toda, Iwao Sasaki, Hiroo Naito, Michinaga Takahashi, Seiki Matsuno

The First Department of Surgery, Tohoku University School of Medicine

Experimental studies were carried out to investigate the effect of ileo-jejunal transposition (IJT) upon the secretion of gastric acid and gastrointestinal hormones. IJT, sham 1 operation and sham 2 operation were constructed in 16 Heidenhain pouch dogs and the following results were obtained. 1) Following IJT hyperenteroglucagonemia was observed. 2) The integrated gastrin resopnse and acid output from Heidenhain pouch after test meal loading were markedly elevated in the IJT group. 3) The plasma gastric inhibitory polypeptide (GIP) levels at 60 to 90 minutes after the test meal were significantly decreased in the IJT group. In conclusion, hyperenteroglucagonemia and a marked rise in gastric acid output were observed after IJT. These observations do not support the idea that enteroglucagon has an enterogastrone effect. The release of GIP was not found to be affected by hyperenteroglucagonemia.

Key words
gastric acid secretion, biliary diversion, enterogastrone, enteroglucagon, gastric inhibitory polypeptide

Reprint requests
Morihiko Toda Department of Surgery, Towada City Central Hospital
12-14-8 Nishi, Towada, 034 JAPAN

Accepted
November 8, 1989

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