The Effect of Hemostatics on Adhesive Ileus

Motonori Okino, Hiroshi Tomie, Norichika Matsui, Kohichi Ueki, Nobuyoshi Morita, Kensuke Esato

The First Department of Surgery, Yamaguchi University School of Medicine

We studied the correlation between postoperatively administered hemostatics and the incidence of adhesive ileus in 226 patients with gastric cancer, retrospectively. The incidence of adhesive ileus was 14% (20/149) in the menatetrenone-treated group and 3.9% (3/77) in the non-treated group. There was a significant difference between these two groups. In the group in which the patients had been given more than 400 mg of menatetrenone, the incidence of adhesive ileus was l8.8% (6/32), about four times that of the non-administered group. In the patients who had been administered other hemostatics (carbazochrome sodium sulfonate, tranexamic acid, hemocoagulase, conjugated estrogens), adhesive ileus did not occur more frequently than in the patients who had not been given the hemostatics. Prophylactic administration of a large dose of menatetrenone must be avoided, since the incidence of adhesive ileus may be increased by menatetrenone.

Key words
adhesive ileus, hemostatics, menatetrenone, gastric cancer, gastrectmy

Reprint requests
Motonori Okino First Department of Surgery, Yamaguchi University School of Medicine
1144 Koguchi, Ube, 755 JAPAN

Accepted
November 8, 1989

To read the PDF file you will need Abobe Reader installed on your computer.