Effect of Fat Loading Test on Alteration of Plasma Lipids and Gastrointestinal Hormones in Dog with Ileo-jejunal Transposition

Morihiko Toda, Iwao Sasaki, Hiroo Naito, Yuji Funayama, Yasuhiko Kamiyama, Michinaga Takahashi, Kohei Fukushima, Seiki Matsuno

The First Department of Surgery, Tohoku University School of Medicine

Experimental studies were carried out to investigate the effect of ileo-jejunal transposition (IJT) upon the plasma lipids and gastrointestinal hormones after the oral administration of butter (2 g/kg). Dogs undergoing either IJT (n=6) or sham operation (n=5) were compared and the following results were obtained. 1) In both the UT and the sham groups the plasma triglyceride levels at 0 to 30 minutes after the ingestion of butter significantly increased after the operation. The plasma free fatty acid and cholesterol levels showed no differences after surgery. 2) Five weeks after UT, a significant increase in the fasting plasma total glucagon-like immunoreactivity (total-GLl) level was observed, but the postprandial plasma total-GLI level showed no difference after IJT. 3) The plasma gastric inhibitory polypeptde response to butter ingestion was lower after IJT. The plasma gastrin and insulin levels showed no differences after IJT. The present studies suggest that the absorption of fat is not found to be affected by IJT. Digestion of intraluminal fats may play an important role in the release of enteroglucagon.

Key words
short bowel syndrome, enteroglucagon, gastric inhibitory polypeptido, ileo-jejunal transposition, digestion and absorption of the fat

Reprint requests
Morihiko Tada The Department of Surgery, Towada City Hospital
14-8 Nishijyunibanmachi, Towada, 034 JAPAN

Accepted
November 8, 1989

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