Cefuzonam Penetration into Abdominal Cavity after Hepatectomy

Takumi Hanai, Jiro Yura, Moritsugu Tanaka, Takashi Hashimoto, Keiichi Hori, Kenji Ogino, Akira Mizuno

The First Department of Surgery, Nagoya City University Medical School

Cefuzonam (CZON) was administered to 11 patients with hepatectomy who had a high risk of complication by abdominal infection, and its intracorporeal kinetics was investigated. Five of the patients had hepatic cirrhosis and six cases did not. After intravenous injection of 1 g of CZON the concentrations of CZON in the blood on urine and ascites on 1., 2. and 3. POD were investigated. The concentrations were measured by bioassay. CZON concentrations in the blood on 1. POD in the hepatic cirrhosis group and the non-hepatic cirrhosis group showed peak values at 1 hour of mean 37.1 and 30.2 µg/ml respectively. The concentrations in urine at 2 hours on ench postoperative day, excluding 3. POD of the hepatic cirrhosis group, gave the highest mean concentrations from 1,980 to 3,825 µg/ml in both groups, indicating delayed excretion. The concentration in ascitic fluid showed a peak value of 21.9 µg/ml only in the 2 hour-value on 1. POD in the hepatic cirrhosis group, without much change in the other time periods. Eight-hour values on 1., 2. and 3. POD in both groups gave higher mean values, from 6.3 to 12.5 µg/ml. In the prophylactic administration of CZON at 3 g/day this drug migrates in a higher concentration into the ascitic fluid and seems to be valuable as a prophylactic against abdominal infection.

Key words
hepatectomy, prophylactic administration of antibiotics, cefuzonam, intraabdominal penetration

Reprint requests
Takumi Hanai First Department of Surgery, Nagoya City University Medical School
1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya, 467 JAPAN

Accepted
January 10, 1990

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