Effect of Urosodeoxycholic Acid on Bile Composition after Release of Biliary Obstruction

Masami Hoshino, Yoshihisa Koyama, Rikiya Abe

Department of Surgery, 2, Fukushima Medical College

Changes in hepatic secretion of primary bile acids (CA, CDCA) and bilirubin after oral administration of ursodeoxycholic acid (UDCA) (500 mg/body) were studied seven days after biliary decompression in 15 patients with malignant obstructive jaundice. Five patients with T-tube drainage after biliary tract lithotomy were used as the control. The results were as follows. 1) Bile flow was increased and reached a peak on 90 minutes after UDCA administration, then decreased gradually. 2) UDCA excretion was increased gradually in both the jaundice and the control group, but the rate of increase until 180 minutes was lower in the jaundice group than in the control group. 3) Before UDCA administration, CA secretion was 11.67±6.5 mg/30 minutes in the jaundice group and 33.7±7.0 mg/30 minutes in the control group. CA secretion was faster and in 60 minutes reached a peal that was approximately 50% higher than that before UDCA administration in both groups. Hoever, in a later stage CA secretion tended to remain at a high level in the jaundice group and diminished rapidaly in the control group. 4) Changes in CDCA secretion appeared to be similar to those in CA secretion. 5) After UDCA administration, bilirubin excretion was markedly increased in the patients who showed a prompt decrease in serum bilirubin. UDCA administration is thought to promote the synthesis of hepatic bile in patients with malignant obstructive jaundice after release of biliary obstruction.

Key words
obstructive jaundice, bile acid, bile secretion, ursodeoxycholic acid, cytoprotection of the hepatic cell

Reprint requests
Masami Hoshimo Department of Surgery 2, Fukushima Medical College
l Hikarigaoka, Fukushima, 960-12 JAPAN

Accepted
February 14, 1990

To read the PDF file you will need Abobe Reader installed on your computer.